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Participants are aged between 18 and 64 and have previously undergone at least two unsuccessful treatments for their depression. The patients receive two separate doses of psilocybin, three weeks apart. The study will track improvement in depression levels over seven weeks, and then again at six and 12 months, while also measuring the impact of the trial on the family members themselves. By including 60 participants, the trial aims to determine if this family-centered model is a more effective treatment. familytherapyxxx shrooms q freak 29072024