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Krasnov V.S.
Pavlov First St. Petersburg State Medical University
Kolontareva Yu.M.
Novartis Pharma LLC
Siponimod: a new view at the therapy of secondary progressive multiple sclerosis
Krasnov VS, Kolontareva YuM. Siponimod: a new view at the therapy of secondary progressive multiple sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry.
2021;121(7):124‑129. (In Russ.)
https://doi.org/10.17116/jnevro2021121071124
Siponimod is a selective modulator of sphingosine-1-phosphate (S1P) receptors of types 1 and 5, registered in the Russian Federation for the treatment of patients with secondary progressive multiple sclerosis (SPMS), regardless of the presence or absence of exacerbations. The effectiveness of the drug in comparison with placebo was demonstrated in patients with SPMS in the international clinical trial EXPAND (phase III). This review devotes actual problems in the treatment of patients with SPMS, discusses the pathophysiology of multiple sclerosis progression, describes the peripheral and central mechanisms of siponimod action and its differences from fingolimod. According to analysis of scientific literature experimental, clinical and neuroimaging data are presented, which could explain the reasons for the successful use of siponimod in patients with SPMS, taking into account the pathophysiological mechanisms of the development of progression and the mechanisms of drug action.
Pavlov First St. Petersburg State Medical University
Kolontareva Yu.M.
Novartis Pharma LLC
Received:
20.04.2021
Accepted:
04.06.2021
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So, what are you waiting for? Grab your keyboard, head to one of the top sites we've listed, and start your journey to becoming a Haxball legend today. Good luck and have fun on the virtual pitch
Haxball is one of the most addictive physics-based multiplayer games on the internet. Mixing the simplicity of air hockey with the strategy of football, it has captured the attention of gamers worldwide. However, school and workplace networks frequently block access to the official site.
Unblocked HaxBall Top: Your Guide to Playing the Ultimate Soccer Game Anywhere
These sites specialize in bypassing filters by hosting browser games on independent servers:
Enable hardware acceleration in your browser settings (Chrome, Edge, or Firefox) to offload physics rendering to your GPU.
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