Picking up right where the fifth season left off, newlyweds Mitchell and Cameron (famously known as "Cam") are adjusting to married life. However, the "honeymoon" phase is short-lived as they face new challenges of wedded bliss. Meanwhile, Phil and Claire face their own domestic hurdles, including annoying neighbors, a disastrous Thanksgiving dinner, and Claire's habit of online snooping.

Season 6 continued the show’s historic run, further cementing its status after winning five consecutive Emmy Awards for Outstanding Comedy Series.

: The season builds toward Alex graduating from high school as co-valedictorian, leading to her acceptance at Caltech. Gloria’s Citizenship