Pharmacology In Drug Discovery And Development -

, and begins with thousands of candidates to find just one success. Phase 1: The Detective Work (Discovery)

If a compound shows promise in preclinical studies, it advances to the clinical phase, where it is tested in humans. Pharmacology continues to play a vital role in this phase by: pharmacology in drug discovery and development

For example, in the discovery of statins (HMG-CoA reductase inhibitors), pharmacological validation proved that inhibiting this liver enzyme directly lowered LDL cholesterol. Without this proof, investment in chemical synthesis would be gambling, not science. , and begins with thousands of candidates to